Assessing the effects of the antidepressant venlafaxine to fathead minnows exposed to environmentally relevant concentrations over a full life cycle.

Nest-defense behaviors in fathead minnows after lifecycle exposure to the antidepressant venlafaxine.

Venlafaxine is an antidepressant and anti-anxiety drug that has been detected in municipal wastewater at low μg/L concentrations. In this study, the nest-defense behavior of adult male fathead minnows (Pimephales promelas) was observed in fish exposed for a full lifecycle to venlafaxine nominal concentrations of 0.88, 8.8, and 88 μg/L (i.e. 1, 9.3, 75 μg/L mean measured concentrations). Nest-de...

Fathead Minnow Lifecycle Tests for Detection of Endocrine-Disrupting Substances in Effluents

The goal of this study was to assess the responses of fathead minnows (FHM) exposed to known endocrine-disrupting substances (EDS) in our labs. As well, we wanted to examine the applicability and sensitivity of the full lifecycle FHM test for use on-site, exposing fish to a complex environmentally relevant Canadian effluent. Fathead minnows exposed from the egg stage to ethinylestradiol (EE2, 0...

The Effects of Chronic Exposure to Environmentally Relevant Levels of Water-borne Cadmium on Reproduction in Fathead Minnows

Protective Effects of Simvastatin on Cytotoxicity and Oxidative Stress in Human Gingival Fibroblasts Cells Exposed to Venlafaxine

Background and purpose: Venlafaxine is an antidepressant that belongs to the family of selective serotonin and norepinephrine reuptake inhibitor (SNRIs) drugs. Recent studies have indicated that prolonged use of antidepressants leads to a state where increased formation of reactive oxygen species (ROS) overwhelms body antioxidant protection and subsequently induces DNA damage, lipid peroxidatio...

Metformin Exposure at Environmentally Relevant Concentrations Causes Potential Endocrine Disruption in Adult Male Fish

Pharmaceuticals and personal care products (PPCPs) are emerging contaminants that have been found ubiquitously in wastewater and surface waters around the world. A major source of these compounds is incomplete metabolism in humans and subsequent excretion in human waste, resulting in discharge into surface waters by wastewater treatment plant (WWTP) effluent. One pharmaceutical found in particu...